The photo, posted just two weeks ago, features Gomez wearing a red tank top with smokey-eyed make-up while sipping coke from a striped straw.
"When your lyrics are on the bottle," she captioned it, referring to the lyrics from her song "Me & the Rhythm" which were displayed on the bottle.
The now most-liked photo surpasses the previous most-liked picture by about 400,000 likes.
Gomez is also the most followed person on Instagram with over 89 million followers.