Jenner was married to Simpson's attorney Robert Kardashian, who will be played by "Friends"n star David Schwimmer on the TV series, reported E! Online.
The show marks 48-year-old Schwimmer's full-fledged return to TV after "Friends" ended in 2004.
The event series has cast John Travolta (Robert Shapiro), Cuba Gooding Jr (OJ Simpson), Sarah Paulson (Marcia Clark), Courtney B. Vance (Johnnie Cochran), Connie Britton (Faye Resnick) and Jordana Brewster (Denise Brown).