Rubio, 43, told top donors he is running for the Republican nomination because the 2016 race for the White House should be about the future, not the past. A Cuban- American serving his first term as senator, Rubio also said he feels "uniquely qualified" to pitch his Republican Party as one that will defend the American Dream.
Rubio's presidential announcement comes a day after Clinton announced her bid for the Democratic nomination and as the former secretary of state is traveling to early voting state Iowa on her first trip as a candidate.
"The Republican Party, for the first time in a long time, has a chance in this election to be the party of the future," Rubio told his donors. "Just yesterday, we heard from a leader from yesterday who wants to take us back to yesterday, but I feel that this country has always been about tomorrow."
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Rubio is the third major Republican contender to declare himself a candidate, after Texas Senator Ted Cruz and Senator Rand Paul, in a field that could grow to 20 or more candidates.
Rubio spoke on a conference call with donors before a flashy political rally set for today night in Miami.
In previewing his campaign's central message, Rubio said the dream is slipping from too many families' grip, and young Americans face unequal opportunities to succeed. It was a message honed to pitch his party as one that cares about all voters, not just those in upper tax brackets.
A young man in a hurry, Rubio will no doubt hear rivals tell voters he's not ready for the White House. To counter that, Rubio has outlined specific policy proposals that boost him as a policy expert, both on foreign and domestic issues.