The BSE-30 share index, Sensex, resumed lower at 20,785.20 and dropped further to 20,645.64 before quoting at 20,741.67 points at 1030 hrs, showing a loss of 81.10 points, or 0.39 per cent, from its last close.
The NSE 50-share barometer Nifty also moved down by 27.80 points, or 0.45 per cent, to 6,159.45 at 1030 hrs.
Major losers were - HDFC (2.16 per cent), ONGC (1.38 per cent), Gail India (1.32 per cent), Maruti Suzuki (1.17 per cent) and TCS (1.13 per cent).
Key benchmark indices in Singapore, China, Japan, Hong Kong, Taiwan, Indonesia and South Korea shed 0.3 to 1.06 per cent.
US stocks tumbled yesterday as speculation the Federal Reserve may scale back stimulus amid faster-than-estimated economic growth overshadowed a move by the European Central Bank to cut a key interest rate.
Meanwhile, foreign institutional investors continued their buying spree by investing net Rs 479.24 crore yesterday, as per the provisional data issued by stock exchanges.