Some buying activity is seen in Metal, Oil & gas, Healthcare, Power and Consumer Durables stocks.
The Sensex opened higher at 28,443.23 and moved in a range of 28,483.41 and 28,361.97. At 1100 hrs, the 30-share barometer was quoted lower by 61.92 pts, or 0.22 per cent, at 28,377.36.
The NSE 50-share Nifty was also down 21.05 points, or 0.24 per cent, at 8,780 at 1100 hrs.
However, SunPharma rose by 0.92 per cent, ITC 0.63 per cent, Tata Steel 0.62 per cent, Cipla 0.58 per cent, Asianpaints 0.53 per cent, GAIL 0.51 per cent.
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Meanwhile, Foreign portfolio investors (FPIs) sold shares worth a net Rs 449.52 crore yesterday, as per provisional data released by the stock exchanges.
Overseas, appetite for Asian stocks and the Euro evaporated early today as economic and political fears sent investors seeking shelter in the yen, while forecasts of China's foreign exchange reserves has fallen for a seventh month added to jitters.