Meanwhile, the consensus is that the Fed will leave rates unchanged, but investors are looking for commentary and the guidance for the next interest rate hike.
"Investors are widely expecting status quo on interest rate, however, any hawkish commentary from the Fed may divert the liquidity to safe haven assets and add volatility to the domestic market," said Vinod Nair, Head of Research Geojit BNP Paribas Financial Services.
In stock specific action, Jubilant FoodWorks plunged 6.08 per cent to Rs 944.15 following news that its CEO and Whole- time Director Ajay Kaul will resign to pursue opportunities outside the company.
The 30-share index declined by 111.30 points or 0.39 per cent to 28,523.20 after shuttling between 28,698.81 and 28,480.53. The gauge had gained 281 points in the previous four sessions on positive global cues.
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Market stayed in the negative almost throughout the day as participants were seen trimming positions to book profits in recent gainers coupled with caution across the global ahead of Fed and Bank of Japan policy meets this week.
In line with the overall trend, the small-cap index shed 0.26 per cent, while the mid-cap lost 0.09 per cent.
Other Asian markets too closed lower and European shares were down as sentiment across the globe remained muted.
"The optimism in US Fed chair speech on the US job market
and unwinding of FII inflows are keeping emerging markets less attractive," said Vinod Nair, Head of Research, Geojit BNP Paribas Financial Services.
The market breadth remained negative as 1,777 stocks ended lower, 832 closed higher while 144 ruled steady.
The total turnover on BSE amounted to Rs 2,470.27 crore, slightly higher than Rs 2,422.75 crore registered during the previous trading session.