The 30-share index fell 105.68 points, or 0.41 per cent, to 25,413.54. The gauge had lost 284.54 points in the previous session on Friday.
On similar lines, NSE Nifty edged lower by 28.50 points, or 0.36 per cent, to 7,733.45.
Brokers said profit-booking in recent gainers amid the prevailing uncertainty over passage of the GST Bill dampened sentiment.
Besides, a mixed movement at other Asian markets and weekend losses in the US and European markets triggered selling, they said.
The US Dow Jones ended 2.10 per cent lower in Friday's trade.