The 30-share barometer, which had lost 562.34 points in the past three sessions, fell another by 107.22 points, or 0.56 per cent, to 18,900.88.
Stocks of consumer durable, capital goods, auto, oil and gas and banking sectors declined due to profit-booking.
Similarly, the wide-based National Stock Exchange index Nifty fell by 33.15 points, or 0.58 per cent, to 5,712.80.
Brokers said investors and funds adopted a cautious approach, following fresh development on the political front as DMK withdrew its support to the ruling UPA government.