The 30-share index declined by 108.97 points, or 0.39 per cent, to 27,287.41. The gauge had gained 219.39 points in the previous session.
In similar fashion, the National Stock Exchange index Nifty edged down by 33.40 points, or 0.40 per cent, to 8,252.20.
Brokers said apart from offloading of positions in some bluechip stocks in view of April's derivatives expiry tomorrow and a weak trend at other Asian markets dampened the sentiments.
Country's largest telecom company Bharti Airtel yesterday reported a 30.5 per cent jump in its March quarter's net profit at Rs 1,255 crore.
Among other Asian markets, Hong Kong Hang Seng was down by 0.50 per cent, while financial markets in Japan are closed today for a public holiday.
The US Dow Jones Industrial Average ended 0.40 per cent higher in yesterday's trade.