The 30-share index, which had lost 81.61 points yesterday, fell by another 144.44 points, or 0.66 per cent, to 21,630.17 in early trade with all the sectoral indices led by banking, realty and metals trading in the negative zone, with losses up to 1.31 per cent.
The broader Nifty of the National Stock Exchange too moved down by 36.05 points, or 0.56 per cent, to 6,457.05.
In other Asian markets, Hong Kong's Hang Seng fell by 0.66 per cent, while Japan's Nikkei moved down by 2.73 per cent in early trade today.
The US Dow Jones Industrial Average lost 1.41 per cent in yesterday's trade.