Consumer durables, banking and refinery sector stocks declined, while realty and capital goods shares attracted buying. HDFC, Maruti Suzuki, ONGC and Bajaj Auto were the major losers on the index.
A weak trend prevailed in Asian and European markets on concerns the Fed would reduce its bond-buying programme earlier than anticipated following initial signs of strength in the US economy. Cautious investors booked profits, leading to a fall in stocks globally, including in India.
The Sensex came off an all-time closing high of 21,239.36 on Diwali to post its biggest weekly drop in seven.
The Nifty on the National Stock Exchange dropped 46.50 points, or 0.75 per cent, to end at a 2-week low of 6,140.75. The SX40 index on the MCX Stock Exchange fell 119.6 points.
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"Markets will watch out for the remaining quarterly results in the next week. Early next week, markets will also focus on the outcome of China's Plenum, where significant reforms measures are expected," said Dipen Shah, Head of Private Client Group Research at Kotak Securities.
Among bank stocks, Punjab National Bank slumped 4.21 percent after Q2 profit fell 52.56 per cent. UCO Bank, which posted a 4-fold increase in earnings, shot up 5.28 per cent.
Brokers said the market also remained under pressure as the rupee dropped to a six-week low of 62.75 against dollar.
In Asia, key indices in Singapore, China, Japan, Hong Kong, Taiwan and Korea fell in 0.60-1.09 per cent range. European stocks were also lower in early trade.