The 30-share index, which has gained a moderate 13.66 points in the previous session, declined by 25.09 points, or 0.12 per cent, to 21,728.66 with oil and gas, PSUs and healthcare sectoral indices leading the fall.
In a similar fashion, the wide-based National Stock Exchange index Nifty was down 7.75 points, or 0.12 per cent, at 6,485.45.
Brokers said besides profit-booking by participants after yesterday's gains, absence of any cues from the global markets mainly influenced the trading sentiments here.