The 30-share index, which had lost 385.73 points in the previous two sessions, fell by another 51.25 points, or 0.20 per cent, to 25,139.23 in early trade with FMCG, realty, power, banking, oil and gas, capital goods and PSU sector stocks leading the fall.
The broader Nifty of the National Stock Exchange too moved down by 4.95 points, or 0.07 per cent, to 7,528.60.
Rising prices of essential food items like vegetables, fruits and cereals, pushed up inflation to five-month high of 6.01 per cent in May.
Continued selling by foreign funds and retail investors largely after the rupee weakened to a fresh six-week low of Rs 60.50 also dampened the trading sentiments here.
In other Asian markets, Hong Kong's Hang Seng fell by 0.27 per cent, while Japan's Nikkei moved up by 0.50 per cent in early trade today.