A mixed trend at other Asian markets as investors turned cautious ahead of the US Fed rate decision later this week weighed.
The 30-share barometer, which had gained 246.49 points in yesterday's session, was trading down 54.91 points, or 0.21 per cent, at 25,801.79, with metal, banking, auto and power sector stocks leading the losses.
On similar lines, the NSE Nifty shed 27.15 points, or 0.34 per cent, at 7,845.10.
Brokers said sentiment turned somewhat weak as investors booked profits after yesterday's gains even as retail inflation fell to a new low of 3.66 per cent in August, which may prompt the Reserve Bank to cut rates at its September 29 policy meet.
The US Dow Jones Industrial Average ended 0.38 per cent lower in yesterday's trade.