The 30-share barometer, which had gained nearly 620 points in the last four sessions, lost 57.30 points, or 0.33 per cent, to 17,200.08. Stocks of auto, metal and capital goods sectors led the fall.
Similarly, the wide-based National Stock Exchange index Nifty declined by 18.70 points, or 0.36 per cent, to 5,211.80.
Brokers said besides profit-booking by participants, mixed trend in other Asian markets influenced the sentiment.
They said reports of Goldman Sachs Group cutting its economic growth forecast for the second time in two months also dampened the sentiment.
In the Asian region, Hong Kong's Hang Seng index was down marginally by 0.33 per cent, while Japan's Nikkei Index edged higher by 0.32 per cent in early trade today.