This was after the US Federal Reserve pressed on with cuts to US economic stimulus and a report showed contraction in China's manufacturing industry.
Profit-booking from operators in view of last day of the futures and options January contract also affected the market sentiment.
The sensex resumed lower at 20,491.74 and hovered in a range of 20,501.92 and 20,415.02 before quoting at 20,432.71 at 1030hrs, showing a loss of 214.59 points or 1.04 per cent from its last close.
Major losers were SSLT 3.04 pct, Hindalco 2.95 pct, Icici Bank 2.41 pct, BHEL 2.34 pct, Tata Steel 2.25 pct and ITC 1.78 pct.
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After a monetary policy review, the Federal Open Market Committee (FOMC) yesterday announced that it will reduce monthly bond purchases by another USD 10 billion to USD 65 billion.
In Asia, indices in Hong Kong, China, Singapore, Japan and Indonesia fell by 0.48 pct to 3.33 pct. Stock markets in South Korea and Taiwan are closed today and Hong Kong and Singapore will shut early for the Chinese New Year holidays.