The rupee, which further weakened by more than 20 paise against the dollar, too kept domestic equities under pressure.
The broader markets however outperformed the Sensex with the small-cap index ending 0.36 per cent higher while mid-cap gained 0.12 per cent.
Power stocks tumbled 0.65 per cent and power sector shares took a hit of 0.70 per cent.
Shares of SpiceJet dropped 3.25 per cent, InterGlobe fell 3.09 per cent and Jet Airways lost 1.53 per cent.
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In sweeping reforms, the Centre yesterday eased Foreign Direct Investment (FDI) norms in civil aviation, single-brand retail, defence and pharma by permitting more investments under automatic route.
After opening higher, the BSE 30-share Sensex touched a high of 26,925.64 but slipped later to 26,754.60 before ending down by 54.14 points or 0.20 per cent at 26,812.78.
NSE Nifty after shuttling between 8,257.25 and 8,202.15 settled 18.60 points or 0.23 per cent lower at 8,219.90.
"Following the sharp rally yesterday, participants decided to take money off the table and book profits. Also, sentiment is now veering towards risk-off, as the date for the Brexit referendum inches closer," said Shreyash Devalkar Fund Manager - Equities, BNP Paribas Mutual Fund.
Overseas, Japan's Nikkei surged 1.28 per cent, Hong Kong's Hang Seng gained 0.77 per cent while Shanghai Composite Index down 0.35 per cent.
ended lower.
Major losers were Adani Ports (1.72 pc), NTPC (1.43 pc), Axis Bank (1.37 pc), Asian Paints (1.18 pc), SBI (0.88 pc), HUL (0.88 pc), Cipla (0.78 pc), Lupin (0.78 pc) and GAIL (0.78 pc).
However, ONGC rose 1.68 per cent followed by M&M (0.92 pc), Tata Motors (0.70 pc), Wipro (0.59 pc) and HDFC (0.38 pc).
Among sectoral indices, utilities dropped by 0.78 per cent followed by power (0.70 pc), bankex (0.65 pc) and healthcare (0.40 pc) while auto gained 0.58 per cent, consumer durables rose 0.39 per cent and oil&gas went up 0.34 per cent.
The total turnover fell to Rs 2,509.47 crore from Rs 2,704.31 crore yesterday.