Shares of Power, Refinery, Auto, Capital Goods and PSU declined due to heavy selling pressure from investors.
However, shares of IT and Tech firmed up on good demand from investors due to weakness of rupee against the dollar.
Tepid monsoon forecast and slowdown in buying by foreign funds, who have been major buyers on the domestic bourses, have dampened sentiments, brokers said.
Rising tension in Iraq which drove oil prices to 9-month high and increase in wholesale inflation weighed on stocks.
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The Sensex resumed slightly higher at 25,239.50 and firmed up further to a high of 25,609.28 on initial strong buying. But declined afterwards to 25,056.18 before settling the week at 25,105.51, disclosing a loss of 122.66 points or 0.49 per cent.
It has lost 290.95 points or 1.15 per cent in two weeks.
The NSE 50-share Nifty also dropped by 30.65 points, or 0.41 per cent, to 7,511.45.