The 30-share barometer, which had lost 738.38 points in the previous three sessions, fell by 102.96 points, or 0.38 per cent, to trade at one-month low of 26,365.40.
All the sectoral indices, led by consumer durables, FMCG, healthcare, banking and capital goods, were trading in negative territory with losses about up to 0.99 per cent.
Similarly, the National Stock Exchange index Nifty fell by 27.00 points, or 0.34 per cent, to 7,884.85.
A subdued trend at other Asian markets in line with overnight sell-offs on the US market also triggered selling by funds, they added.
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Besides, weakening rupee that depreciated by another 15 paise against the dollar to trade at fresh seven-week low of 61.49 in early trade today had a negative impact, brokers said.
Among other Asian markets, Japan's Nikkei was down 0.98 per cent, while Hong Kong's Hang Seng shed 0.23 per cent in early trade.