Besides, a subdued trend on Asian bourses also dampened the trading sentiments here.
The 30-share barometer, which gained nearly 215 points in the previous two sessions, fell by 62.38 points, or 0.33 per cent, to 18,729.55.
Stocks of oil and gas, metal, capital goods, banking and auto sectors fell due to profit-booking.
Similarly, the wide-based National Stock Exchange index Nifty shed 19.45 points, or 0.34 per cent, to 5,699.25.
Brokers said besides profit-booking by speculators after recent gains, a weak trend in Asian trade following overnight losses at the US market, influenced the sentiments here.
In Asian region, Japan's Nikkei Index shed 0.43 per cent, while Hong Kong's Hang Seng index remained almost flat in early trade today.
The US Dow Jones Industrial Average ended 0.06 per cent down in yesterday's trade.