Besides, caution before the expiry of October series contracts in the derivatives segment tomorrow, influenced sentiments.
Although the Federal Reserve is likely to keep interest rates unchanged, investors are looking forward to clues on the timing of a widely expected rate hike.
In last three days, the Sensex has lost 431.05 points.
Globally, Asian markets traded mixed while European bourses were higher in early trade.
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The 30-share BSE Sensex opened a shade lower at 27,131.71 and fell further to hit a low of 26,919.96 on across-the-board losses, mainly in banking, power and realty stocks.
The index finally settled 213.68 points, or 0.78 per cent, down at 27,039.76, its weakest closing since October 15.
The broader 50-share NSE Nifty dipped below the crucial 8,200-mark, by plunging 61.70 points, or 0.75 per cent, to close at 8,171.20 after shuttling between 8,209.10 and 8,131.80 during the day.
Out of the 30-Sensex constituents, 19 ended lower.
Bucking the trend, Cipla, Bharti Airtel, ONGC, Tata Motors, Hindustan Unilever, Wipro, Tata Steel, Infosys, Vedanta and HDFC Bank ended up to 1.64 per cent higher.
Sectorwise, the BSE Banking index suffered the most by falling 2.53 per cent, followed by Power (1.48 per cent), Realty (1.24 per cent), PSU (0.76 per cent), Auto (0.65 per cent) and Healthcare (0.50 per cent).
The broader markets also showed weakness with the BSE mid-cap index ending 0.55 per down while the small-cap fell 0.01 per cent.