At an appearance before an economic group on Wednesday, she said she is "looking forward" to an interest rate hike, which sparked concerns about capital outflows from emerging markets.
Mood remained downbeat after a monthly survey showed that services sector output stagnated in November after four straight months of expansion.
The BSE Sensex touched a low of 25,857.35 before settling at 25,886.62, a fall of 231.23,or 0.89 per cent -- its biggest single-day drop since November 18.
The 50-share NSE Nifty went below the crucial 7,900-mark and closed lower by 67.20 points, or 0.85 per cent, at 7,864.15. It shuttled between 7,853.30 and 7,912.30 during the day.
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ONGC tanked the most, with a fall of 2.65 per cent, followed by Lupin and BHEL.
Moreover, Vedanta Ltd, ITC, M&M, Tata Motors, Hero MotoCorp and ICICI Bank were down by up to 2.23 per cent.
Stocks of IT and auto came under selling pressure as incessant rains in Chennai and other parts of Tamil Nadu hit their operations hard.
Sectorwise, BSE FMCG suffered the most plunging 1.48 per cent, followed by consumer durables, metal, PSU and healthcare.
In step with the overall trend, the small-cap index fell 0.50 per cent while the mid-cap index shed 0.42 per cent as investors reduced their bets.
Asian markets showed a mixed trend at the close while Europe was trading higher in opening trade on expectations that ECB will ramp up its stimulus programme.
Foreign portfolio investors (FPIs) after remaining net sellers on Indian markets for several sessions bought shares worth a net Rs 60.61 crore yesterday, provisional data by stock exchanges showed.