This sent the rupee steeply lower by 42 paise to 67.85 (intra-day) against the dollar, which fed the nervous cycle.
The session saw strong spells of volatility amid sustained foreign funds outflows.
The quarter percentage point rate increase -- the first this year -- was a virtual certainty although investors were caught off-guard after the Federal Reserve indicated that the pace of the tightening will be quicker in 2017.
The gauge had lost 95 points in the previous session.
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The NSE Nifty fell 28.85 points, or 0.35 per cent, at 8,153.60. Intra-day, it hovered between 8,121.95 and 8,225.90.
The benchmark indices contained the losses on the back of buying in IT stocks supported by a strong dollar against the rupee.
Sentiment took a hit as fears grew that a rate hike in the US would mean higher pace of capital outflows from emerging markets, including India, into US bonds that are considered as safer investment options, brokers said.
But TCS, the country's leading IT exporter, continued its upward journey for yet another day and ended 2.34 per cent higher on expectations that a rising dollar against the rupee will improve its earnings.
Out of 30-share Sensex constituents, 18 ended lower, while 12 finished in the green.
Global markets also ruled mixed after the US Fed, as expected, hiked rates by 0.25 per cent.
Among other Asian markets, Hong Kong's Hang Seng fell 1.77 per cent and Shanghai Composite shed 0.73 per cent while Japan's Nikkei was up 0.10 per cent.
The BSE healthcare index suffered the most by falling 1.36 per cent, followed by FMCG 0.80 per cent, consumer durables 0.79 per cent and auto 0.32 per cent.
In sync with the trend, the small-cap index rose 0.21 per cent and mid-cap ended almost flat.
Shares of Gitanjali Gems climbed 6.70 per cent to close at Rs 66.85 after the company said its September quarter net profit jumped 48 per cent and its subsidiary Nakshatra World notified the decision of raising up to Rs 650 crore through an IPO.