The 30-share index was trading lower by 85.51 points, or 0.32 per cent, at 26,501.04 as banking, oil & gas, capital goods, PSU and IT sector stocks succumbed to profit-booking.
The gauge had advanced 215.57 points in the previous two sessions on strong factory output data and steady inflation.
Similarly, the Nifty slipped below the 8,000 mark by falling 35.45 points, or 0.44 per cent, at 7,978.45.
Among other Asian markets, Hong Kong's Hang Seng was down 0.49 per cent while Japan's Nikkei shed 0.63 per cent in early trade today.
The US Dow Jones Industrial Average ended 0.60 per cent down in yesterday's trade.