The rupee depreciated against US dollar to 61.14 levels, further dampening market sentiments, said equity brokers.
Wary market participants preferred to book profits as they expected early hike in interest rates by the US Federal Reserve. Higher US rates is likely to trigger capital outflows in emerging markets, including India. Fed's two-day policy setting meeting starts tomorrow.
Refinery, IT, capital goods and FMCG stocks in Indian markets also attracted profit-booking while some of the pharma and realty counters closed with gains, said traders.
The BSE 30-share Sensex resumed lower in line with sluggish Asian trends on the back of Friday's fall on Wall Street. It gradually moved down further to settle at a two-week low of 26,816.56, down 244.48 points or 0.90 per cent. Today's drop is its worst fall since August 8, 2014.
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Similarly, the 50-issue NSE Nifty also dipped by 63.50 points or 0.78 per cent, also its biggest loss since August 8, to two-week low levels of 8,042.
"Benchmark indices ended lower for the day, driven lower by weak global markets. The policy meeting of the US Fed continued to be in focus. Markets are awaiting signals from the Fed, if any, on the timing of interest rate hikes," said Dipen Shah, Head- PCG Research, Kotak Securities.
Oil prices sank. US benchmark West Texas Intermediate for October delivery eased 74 cents to USD 91.53, while Brent crude for October rose 39 cents to USD 97.50 in afternoon trade.