The broader Nifty of the NSE dropped 0.94 per cent or 96.8 points to end at 10,224.95.
Disappointing macroeconomic data and muted earnings as well as caution ahead of CPI inflation data to be released later in the day hit the market sentiment, brokers said.
A weakening rupee, which depreciated by 35 paise to 65.51 against the dollar during the day on fears that the tax rate decision of the GST Council will have a revenue implication of Rs 20,000 crore annually, too dampened investor sentiment.
The NSE Nifty settled the day 96.80 points, or 0.94 per cent lower, at 10,224.95 after shuttling between 10,334.15 and 10,216.25 during the day.
Industrial production (IIP) grew at a slower pace of 3.8 per cent in September, mainly due to subdued performance of the manufacturing sector coupled with contraction in output of consumer durables.