This is the third straight day of losses for the indices, which fell for the second week on the trot.
Shares of Realty, Power, FMCG, Consumer Durable, Auto and Capital good sectors were major losers of the day.
Small-cap and Mid-cap indices also dropped by 2.14 per cent and 1.49 per cent respectively as retail investors offloaded shares.
"...Markets are...Awaiting the 4Q results, which are expected to be subdued," said Dipen Shah, Head of PCG Research, Kotak Securities.
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The Sensex has now lost 475.30 points or 1.65 per cent in three consecutive days.
Meanwhile, the NSE 50-share Nifty dropped by 63.75 points or 0.74 per cent to end at 8,570.90.
Jayant Manglik, President-retail distribution, Religare Securities said: "Tracking weak global cues, equity benchmarks made a sluggish start and upheld that bias till the end. Besides, depreciation in Indian rupee too weighed down sentiments but that helped IT counters to end in green while all the other sectoral indices reeled under pressure."
Asian markets ended mixed even as investors booked profits after the previous day's rally that was fuelled by the Federal Reserve's dovish stance on interest rates.
Key indices in China, Japan, Singapore and Taiwan ended 0.13 per cent to 0.98 per cent higher while indices in Hong Kong and South Korea fell in 0.03-0.38 per cent range.
European markets were trading higher amid renewed hopes for progress on the Greek debt front. Key indices in the UK, France and Germany were up by 0.07 pct to 0.56 per cent.