The BSE barometer was forced to give up all of its early gains as both the companies, Lupin and Bajaj Auto, reported muted earning numbers for the quarter.
Moreover, weaker rupee against dollar also led to a cautious approach. The rupee was trading 20 paise down at 63.78 (intra-day) at the Forex market.
Resuming higher, the 30-share BSE index shot up to touch the day's high of 28,578.33 in early trade on hopes of passage of the key GST bill and a firming trend at other Asian markets.
The NSE Nifty slipped below 8,600 level by declining 43.70 points, or 0.51 per cent to close at 8,589.80. Intra-day, it shuttled between 8,654.75 and 8,573.80.
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Yesterday, both the indices has surged to their respective three-month highs since April 16 on adoption of a select committee report on GST Bill by the Upper House of Parliament.
On the Sensex, Lupin Lab suffered the most by tumbling 5.23 per cent to Rs 1,728.60 after company reported a 15.96 per cent dip in its consolidated net profit at Rs 525.02 crore for the quarter ended June 30.
Other losers included, Tata Steel, TCS, Bharti Airtel, HUL, L&T, ICICI Bank, Axis Bank, HDFC Bank, Sun Pharma, ONGC, Vedanta, Infosys, Coal India Cipla and BHEL.
Of 30-share index, as many as 18 scrips ended lower.
Sectorally, BSE teck index suffered the most by falling 0.79 per cent, followed by banking 0.71 per cent, capital goods 0.67 per cent and IT 0.65 per cent.