A weak trend in global markets after a data showed slump in Chinese imports, fuelling worries about the health of Asia's largest economy also weighed on the sentiments.
Software stocks remained under pressure for the second straight day after Infosys yesterday slashed its dollar revenue guidance, clouding the outlook for the overall sector.
The 30-share BSE Sensex after shuttling between 26,918.52 and 26,719.10 during the session finally settled lower by 57.58 points or 0.21 per cent at 26,846.53.
Market showed some signs of firmness in early trade on the back of positive macroeconomic data with industrial production grew at a nearly three-year high of 6.4 per cent in August.
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However, retail inflation rising to 4.41 per cent in September, had a negative impact, and triggered selling.
"Indices are struggling to maintain their crucial levels as selling emerges at every rise," said Manoj Choraria, a Delhi-based NSE broker.
A cautious stance from the participants trimming positions ahead of the TCS earnings announcement, later in the day, too influenced trading sentiment.
Sensex losers included ONGC, Hindalco, Vedanta, Tata Steel, Infosys, Bharti Airtel, GAIL, Sun Pharma, L&T, Hero MotoCorp, SBI, Tata Motors, HDFC Bank and HUL.
Bucking the trend, Coal India, Lupin, BHEL, Bajaj Auto, Maruti Suzuki, ITC, Dr Reddy's, Axis Bank, M&M, HDFC, Cipla, NTPC and RIL notched up gains up to 1.79 per cent.
Of the 30-share pack, 15 closed with losses.
Sector-wise, IT suffered the most by falling 1.03 per cent, followed by teck with a drop of 0.87 per cent.
Globally, other Asian markets ended lower with Japan's Nikkei and Hong Kong's Hang Seng falling up to 1.11 per cent, while European markets were showing an easy trend in their opening deals.