The barometer index had slipped by 109 points yesterday as well, bogged down by subdued numbers of heavyweights, Bharti Airtel and HDFC Ltd.
Brokers said, caution ahead of October derivatives expiry on Thursday too influenced sentiment.
Moreover, investors stayed on the sidelines ahead of a two-day meeting of the US Federal Reserve, which starts today.
This is gauge's lowest closing since October 16 and has lost 217.37 points in last two sessions.
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Out of 30 Sensex stocks, 17 ended in the negative zone.
The 50-issue NSE Nifty also dropped by 24.05 points or 0.30 per cent to end at 8,235.40 after shuttling between 8,241.95 and 8,217.05, intra-day.
Market mood took a beating on dismal earnings by Lupin, which posted a 35.11 per cent dip in its net profit at Rs 408.80 crore for the second quarter.
Maruti Suzuki, however, emerged as the top gainer on both the indexes after its Q2 net profit jumped 42.1 per cent to Rs 1,225.6 crore.
Sectorwise, the BSE consumer durables index suffered the most by losing 1.43 per cent, followed by infra 0.77 per cent, capital goods 0.70 per cent, PSU 0.66 per cent, oil & gas 0.66 per cent and metal 0.48 per cent.
Broader markets, however, outperformed the Sensex with BSE mid-cap index rising 0.16 per cent and small-cap gaining 0.15 per cent.