Shares of consumer durable, banking, realty, capital goods, metal, power and refinery sectors declined sharply.
The BSE-30 share index, Sensex, resumed lower at 19,297.11 points and dropped further to a low of 18,852.40 before quoting at 18,892.86 at 1115 hours.
It showed a sharp fall of 474.73 points, or 2.45 per cent, from its last close.
It had gained by 702.71 points or 3.76 per cent in last four sessions.
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Major losers were - BHEL (4.59 pct), HDFC (4.44 pct), Maruti Suzuki (4.24 pct), Tata Power (3.73 pct), Icici Bank (3.59 pct), M&M (3.41 pct), Tata Steel (3.36 pct) and Larsen (3.19 pct).
The market sentiment was also affected by RBI's decision on Wednesday to reduce the limit for Overseas Direct Investment (ODI) under automatic route for all fresh ODI transactions from 400 per cent of the net worth of an Indian Party to 100 per cent of its net worth.
Key benchmark indices in China, Hong Kong, Indonesia, Singapore, South Korea and Japan were down by 0.51 to 1.35 pct.