However, good buying interest was seen in telecom, health care, bank, financials and power counters.
The benchmark Sensex opened higher at 28,270.67 and moved in a range of 28,280.58 and 28,142.23 points before quoting at 28,190.26 at 1045 hrs, showing a loss of 36.35 pts or 0.13 per cent.
The wider NSE Nifty also traded lower by 9.65 points, or 0.11 per cent, at 8,724.60 at 1045hrs.
Notable gainers were Cipla 3.78 per cent, Adani Ports 1.73 per cent, SBIN 1.27, SunPharma 1.03 per cent and ONGC 0.82 per cent.
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Meanwhile, foreign portfolio investors (FPIs) bought shares worth a net Rs 108.59 crore yesterday, as per provisional data released by the stock exchanges.
Domestic institutional investors (DIIs) also bought shares worth a net Rs 1,133.74 crore yesterday.
Overseas, Asian markets were mixed as investors await the outcome of key US monthly jobs report that will set the tone for the Federal Reserve's policy outlook. China's markets reopened after a week-long break.