The 30-share Sensex fell further by 69.39 points, or 0.24 per cent, to 28,269.92 with auto, realty, healthcare and consumer durables stocks leading the fall.
The gauge had lost 12.31 points in the previous session.
The NSE Nifty fell by 17.10 points, or 0.19 per cent, to 8,775.20.
Brokers said that apart from profit-booking in recent gainers by investors, disappointing earnings by some bluechips companies like Tata Motors and Sun Pharma dampened sentiment.
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Stocks of Sun Pharma too plunged by 3.28 per cent to Rs 628.80 on sustained selling by participants after the company reported 4.72 per cent decline in consolidated net profit for the third quarter quarter of 2016-17.
On the other hand, trends at other Asian markets was better in their early session with the Hong Kong's Hang Seng index rising 1.09 per cent, while Japan's Nikkei gained 1.22 per cent. Shanghai Composite Index too was marginally higher by 0.09 per cent.