Williams battled past gallant fellow American Madison Keys while Sharapova demolished Russian compatriot Ekaterina Makarova to ensure the top seeds meet in Saturday's showpiece.
The world's best two players have history and the odds are stacked in Williams' favour, with the 33-year-old holding a major psychological advantage.
She has a 16-2 record against Sharapova, with the Russian five-time Grand Slam champion losing their every encounter since 2004.
There was plenty of friction between the two over Berdych's decision to hire former Murray team member Dani Vallverdu as his coach, with some steely glares at each other during the changeovers.
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"I was disappointed to lose the opening set after I had a couple of chances at the end but I felt I was playing better as the set went on and I was very aggressive at the beginning of the second set," said the British sixth seed.
Awaiting him in Sunday's final will be world number one Novak Djokovic or defending champion Stan Wawrinka, who play their blockbuster semi on Friday.
Despite the ominous statistics, Sharapova has been in outstanding touch and blew away fellow Russian Makarova 6-3, 6-2 on a blustery afternoon on Rod Laver Arena.
She is now in her fourth Australian final, having won in 2008.
Williams was made to work harder by rising teen Keys, who saved eight match points.
Coached by former US great Lindsay Davenport, Keys forced Williams to a first set tiebreak before her illustrious opponent took charge to win 7-6 (7/5), 6-2.