Williams was asked about her use of TUE's following her first round victory over Zarina Diyas of Kazakhstan 7-5, 6-3 at the WTA Indian Wells tournament.
"I have never tested positive. I have always done the TUE so you should fact check that," Williams said.
"I wasn't going to play (the French Open) unless I had a TUE because if you remember that year I was incredibly sick."
Williams insisted she did nothing wrong and that she requested the TUE in 2015 to fight the illness. She skipped practice sessions and needed five three-set wins before eventually claiming the title over Lucie Safarova.
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Reports show Williams was given approval for a TUE for the corticosteroid anti-inflammatory prednisone to help to alleviate the symptoms.
"I don't know how I even won the [tournament], and I said I literally can't play the final," Williams said.
"I have played over 20 years and I have always been extremely honest and that is one thing I take pride on especially having a daughter and having a kid.
"I would never be able to look my kid in the eye and say 'Mom cheated' or Mom did something like that.