70-year-old Sessions, who was the Senator from Alabama since 1997, was confirmed as America's powerful law enforcement officer by surviving a near-party-line vote by 52 to 47.
The final vote for Sessions came after 30 hours of debate from Democrats and a stunning fight between liberal Senator Elizabeth Warren and Senate Republicans which ended in her being forced to sit down after she was accused of impugning Sessions.
One of the first task on his plate is the win the legal battle for the Trump Administration to get the stay lifted on executive order temporarily blocking all refugee arrivals and immigration from seven Muslim-majority countries to the US.
Sessions was one of the first few top Republican Senators to have endorsed Trump in his race to the White House in the Republican primary.
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In the past, Sessions has positioned himself as an opponent of H-1B visas, as he believes that this work visa, popular among Indian IT professionals, displaces American workers.
The fight over Sessions nomination spurred some of the most jarring, and at times personal attacks, rooted in allegations that Sessions was a racist -- claims the Alabama senator and his supporters have fiercely denied.
Senator Dianne Feinstein, the Democratic lawmaker from California attacked Sessions and questioned his credentials.
"We are disappointed that the Senate chose to turn a blind eye to Jeff Sessions' long record of hostility to civil rights. We intend to be relentless in holdingthis Justice Department accountable," said Kristen Clarke, president and executive director of the Lawyers' Committee for Civil Rights Under Law.
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"Sessions really has to reorient the Justice Department to actually advance the interest of the American people and the rule of law, as opposed to subverting it. And he has to depoliticise the Justice Department, so the American people can have faith in the fair administration of justice again," said Judicial Watch president Tom Fitton.
"Attorney General Sessions has nearly 40 years of experience defending justice, civil rights, and the rule of law during his service as a US attorney, the Alabama Attorney General, and a US Senator," she said.
The Republican National Committee (RNC) chairwoman Ronna McDaniel said that that Democrats would try to skew Sessions' strong civil rights record and consistent adherence to rule of law in a partisan effort to block their colleague's nomination shows their only commitment is to blindly obstructing this administration.
"Senator Sessions has had a long history of service to the country and The State of Alabama and dedicated his life to public service. Lost in the midst of this contentious confirmation process is that he loves his country and is a brilliant legal mind," said Alabama-based eminent Indian American Jagdesh Kriplani.