Sethu and Shetty will be part of 'Idemitsu Honda Racing India' by T Pro Ten10, and take part in the Asia Production 250cc class, a release said.
The marquee SuperSport 600cc will see the team's third rider, Japan's Taiga Hada compete with 21 other riders.
Honda Motorcycle & Scooter India Pvt Ltd president and CEO Minoru Kato, said, "Honda 2-Wheelers India is proud to announce that for the first time, an Indian team will be participating solo in the 23rd season of Asia Road Racing Championship (ARRC) 2018.