The car was going to Pratapgarh in Uttar Pradesh from Mumbai when it collided head-on with the private bus near a culvert at Dhanora village on Agra-Mumbai National Highway, police said.
Seven occupants of the car died on the spot while one person was seriously injured, Sarangpur Police Station Inspector Narendra Singh Raghuwanshi said.
The deceased were identified as Mehfooz Khan (70), Sakdar Khan (35), Haider Nazmi (37), Akbari Begum (60) Husna Bi (45) Mariam (10) Dr Yusuf (40), all residents of Pratapgarh in Uttar Pradesh, he said.