The blast took place in the heart of the bustling city centre, between the ruling AKP's offices and those of the governor, Anadolu added, without giving an exact number of the injured.
It was not immediately clear who was behind the blast, which initially appeared to have been caused by a car bomb.
Television images showed water cannon being used to put out a fire caused by the explosion.
Witnesses said the force of the blast shattered the windows in the surrounding vicinity. Several ambulances rushed to the scene.
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The government has stepped up its military campaign in the restive southeast to eradicate PKK militants, who have launched almost daily attacks since the rupture of a fragile ceasefire last year.
Tens of thousands of people have been killed since the PKK first took up arms in 1984, with the aim of carving out an independent state for Turkey's Kurdish minority.
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