The Government's offer to discuss all "constitutional" demands put forth by Khan's Pakistan Tehreek-e-Insaf and Qadri's Pakistan Awami Tehreek did not receive a positive response from the two protesting groups, who have given a 48-hour deadline to Prime Minister Nawaz Sharif to resign.
While Khan's representatives did not respond to the Government's late night calls for formation of two committees, consisting of members from all major political parties, to hold talks, a representative of Qadri said the cleric rejected the proposal outright.
The government is expected to announce the composition of two committees later today to hold separate talks with PTI and PAT leadership to listen to their demands and convince them to call off their sit-ins, that have paralysed life in central Islamabad.
Khan yesterday declared a "civil disobedience movement" against the Sharif government, saying the country's future is bleak under the rule of businessmen.
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The PTI chief has appealed to the people of Pakistan to stop paying utility bills and taxes to the current government.
Khan asserted that under the rule of "these businessmen who only want to make money for themselves, Pakistan's future is bleak."
His remarks were directed at Sharif, one of the country's wealthiest person and the owner of Ittefaq Group.
In the polls last year, Sharif's PML-N had won 190 out of 342 seats. Khan's PTI got 34 seats, the third largest bloc in the legislature. Khan has claimed that his party should have won many more seats but for the vote-rigging by Sharif's PML-N.
The political instability comes at a time when Pakistan is waging a war against militants - particularly in the restive tribal regions along its border with Afghanistan.