The report was prepared by a five-member medical board formed by the Government-run All India Institute of Medical Sciences (AIIMS) based in New Delhi.
"Death in this case is due to asphyxia as a result of strangulation by the way of ligature or manual cannot be ruled out," said the report.
The report also said the human skeleton, sent for examination and believed to be of Sheena's, was of a female aged about 23. It put the time of death at about three years ago.
The report maintained that the body was recovered from a remote place and was suggestive of discrete disposal of corpse and concealment of prime evidence (body).
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"The deceased had skeletal burns (burning of bones) which is only feasible in the case of deep burns. It is observed that there were pan-body burns over skeleton, which suggests the extent of burns were massive and intention was to destroy the whole body to conceal the prime evidence of death investigation."
Sheena was allegedly strangled in a car and then her body was burnt and dumped in a forest in Raigad, about 84 km from Mumbai.
Former media baron Peter Mukerjea, husband of Indrani, was arrested last week for his alleged role in the murder. He is currently in CBI custody.