Cricket Australia Bupa Support Staff Physiotherapist David Beakley said: "Mitchell has been playing with a shoulder injury for most of the summer, which we have been managing up until now, but unfortunately it has progressively deteriorated to a point where he is unable to function at the level required.
"Consequently he will return to Australia to consult with specialists to advise the best course of action," said Beakley.
The National Selection Panel will advise of a replacement player in due course, Cricket Australia said.