Taking advantage of some lacklustre play from Arthi, the strong Shweta, a former India No.3 who is making a comeback after three months due to injury, was quick to run away with the first set with one break of serve.
The second set was a virtual no-contest as Shweta emerged a 6-4 6-0 winner at the suburban Juhu Vile Parle Gymkhana courts.
With both players struggling to hold serves, the heavier ground strokes of Natasha saw her hold the advantage over her opponent.
There were no hiccups for second seed Sharmada Baluu of Karnataka, who announced her good form in this event with a 6-2 6-2 win over Delhi's Samriti Puanyani.
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In men's action, fourth seed Suraj Prabodh of Karnataka beat Chandigarh's Ranjeet Singh 6-3 6-3 while in a match between state mates, Karnataka's S D Prajwal Dev brushed aside Suraj Beniwal 6-1 6-1.
Men (Round 1): Kunal Anand (DEL) bt Raghav Jaisinghani (MP) 6-2 7-6 (7); 4-Suraj Prabodh (KA) bt Ranjeet Singh (CH) 6-3 6-3 ; S D Prajwal Dev (KA) bt Suraj Beniwal (KA) 6-1 6-1; 8-Jayesh Pungaliya (MH) bt Sahil Gaware (MH) 6-3 6-3.
Women (Round 1): 1-Natasha Palha (Goa) bt Lalita Devarakonda (AP) 6-4 4-6 6-2; Shweta Rana (DL) bt 5-Arthi Muniyan (TN) 6-4 6-0; 2-Sharrmada Baluu (KA) bt Samriti Punyani (DL) 6-2 6-1; Baburaj Nithyaraj (TN) bt Saumya Vig (GJ) 6-1 6-2; Nida Kamal (MH) bt Preethi Ujjini (KA) 6-2 5-7 6-0; Nandini Sharma (PB) bt Isha Budwal (MP) 6-4 6-3; Sahan Shetty (KA) bt Dakshata Patel (MH) 6-3 6-2; Himani Mor (HR) bt Neeru Rapria (HR) 6-1 (conceded); Moulika Ram (AP) bt Sagarika Phadke (MH) 6-2 6-1.