The 54-year-old 'X Factor' boss will collaborate with Fleischer Studios, which owns the iconic cartoon character, and Australian digital production house Animal Logic, reported Ace Showbiz.
Betty has made numerous appearances on screen. She appeared on Max Fleischer's 'Talkartoons' and then got her own cartoon series. She also made a cameo in 1988's film 'Who Framed Roger Rabbit'. This upcoming project, however, will be her first music-driven, hybrid animated comedy.
"Betty is an icon, and one of the biggest stars in the world - I'm thrilled to be working with her. Betty, I've worked with some serious divas, but I think you could be the biggest of them all," Simon said of the feisty starlet famous for her trademark bob hair and mini dress.