The 33-year-old actor, who is popular for his role as Howard Wolowitz on 'The Big Bang Theory', confirmed the baby news at the Screen Actors Guild Awards, reported Ace Showbiz.
"Yes, my wife is expecting, - I can't take all the credit," Helberg said.
"Every time I come to the SAG Awards there's something about this night... About 8 months before the SAG Awards I get really the urge, I feel the romance and then we get nominated so it's hand in hand," he added.
Helberg and Towne tied the knot in 2007. The star's actress/writer/director wife gave birth to their first child on May 8, 2012. The couple named their first child, a daughter, Adeline.
In addition to his role on the CBS sitcom, Helberg appeared in other projects including a movie entitled 'A Serious Man' alongside Michael Stuhlbarg and Adam Arkin. He is also known as a voice actor.