Sindhu dumped Japan's Sayaka Takahashi 21-14 21-13 to set up a revenge match against China's Chen Yufei. The World No. 10 Chinese had knocked Sindhu out in the opening round at Denmark Open.
World Championship silver medallist Sindhu had defeated Spain's Beatriz Corrales 21-19 21-18 in the opening round yesterday.
Former World No 1 Saina, however, failed to get across another Japanese World No 5 Akane Yamaguchi losing 9-21 21-23 in a 39-minute clash.
Ashwini Ponnappa and N Sikki Reddy lost 16-21 14-21 to top seeded Japanese Misaki Matsutomo and Ayaka Takahashi in women's doubles.
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Sindhu dominated the opening game as her opponent had a slender lead at 9-8 only once in the opening game while in the second game the Japanese never could topple the Indian though she was competitive initially for sometime.
In another women's singles encounter, Yamaguchi, who had finished as runners-up at Odense last week, tore through the opening game, leading from start to finish to earn the bragging rights.
The Indian caught up with the Japanese at 19-19 and had infact grabbed a game point at 20-19 but Yamaguchi managed to stay ahead and closed out the match.
Yesterday, title-contender Kidambi Srikanth, who had clinched his third title of the season at Denmark Open Super Series premier last week, emerged victories after his opponent Germanys Fabian Roth retired at 0-3 in the opening game.
The World No 8 Indian will face Hong Kongs Wong Wing Ki Vincent, whom he had beaten in straight games last week en route to his title.
They will face Denmark's sixth seed Mads Conrad-Petersen and Mads Pieler Kolding next.