Born around 1947 in Bikaner, Rajasthan, in a Banjara family, Reshma was under treatment after being diagnosed with the disease years ago. She is survived by son Umair and daughter Khadija.
"She had been in coma for the last month and was diagnosed with throat cancer some years ago," said doctor Rahim of the hospital where she was undergoing treatment.
Remembering her origins to the sandy lands in India, she said: "People in India showered me with a lot of admiration. In Pakistan, people have given me respect. But in India also, they listen to me with lot of love. It does not matter to them that I am a Pakistani singer."
Having received no formal education in music, she was only 12 when she was spotted singing at Shahbaz Qalander's shrine by a television and radio producer, who arranged for her to record the iconic song 'Laal Meri' on state-run Pakistan Radio.
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"Singers of that level and magnitude are an institution in themselves and her passing away means a complete era has passed away. It is a huge loss," Shahram Azhar, lead singer of Pakistani band Laal, told PTI.
Some of her famous numbers include 'Hai O Rabba nahion lagda dil mera' and 'Ankhiyan no rehen de ankhyan de kol kol'.
Reshma, who has a massive and loyal fan following, was awarded several national awards including prestigious awards 'Sitara-i-Imtiaz' and 'Legends Of Pakistan' given by the President of Pakistan.