The accident occurred at around 9 AM near Wadi Bunder when the vehicle carrying nine persons was headed to Mumbadevi temple in South Mumbai, they said.
The victims, all residents of Surat, were going to offer prayers when the driver lost control and dashed the vehicle on the road divider, police said.
The onlookers soon alerted the police after which all the injured were rushed to J J Hospital.
The deceased have been identified as Rajkumar Verma (8), Anantra Verma (35), Harkesh Verma (45), Rajshree Verma (35) Ragini Verma (20) and Asha Verma (12), police said.