Sleep increases the reproduction of the cells that go on to form the insulating material on nerve cell projections in the brain and spinal cord known as myelin, researchers said.
The findings could one day lead scientists to new insights about sleep's role in brain repair and growth.
Scientists have known for years that many genes are turned on during sleep and off during periods of wakefulness.
However, it was unclear how sleep affects specific cells types, such as oligodendrocytes, which make myelin in the healthy brain and in response to injury.
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In the current study, Chiara Cirelli, and colleagues at the University of Wisconsin, Madison, measured gene activity in oligodendrocytes from mice that slept or were forced to stay awake.
The group found that genes promoting myelin formation were turned on during sleep. In contrast, the genes implicated in cell death and the cellular stress response were turned on when the animals stayed awake.
"These findings hint at how sleep or lack of sleep might repair or damage the brain," said Mehdi Tafti, who studies sleep at the University of Lausanne in Switzerland and was not involved with this study.
"Now it is clear that the way other supporting cells in the nervous system operate also changes significantly depending on whether the animal is asleep or awake," said Cirelli.
Cirelli speculated the findings suggest that extreme and/or chronic sleep loss could possibly aggravate some symptoms of multiple sclerosis (MS), a disease that damages myelin.
The study was published in the The Journal of Neuroscience.