Researchers at John Hopkins University in the US identified brain cells, located in a part of the hypothalamus called the zona incerta.
These cells could offer novel drug targets to treat sleep disorders, such as insomnia and narcolepsy, caused by the dysfunction of sleep-regulating neurons, they said.
The team described neurons that express a gene called Lhx6. Lhx6-expressing cells have not been observed in this area of the brain before and appear to connect the zona incerta to areas of the brain that control sleep and wakefulness, researchers said.
Normal sleep has two parts, rapid eye movement (REM) and nonrapid eye movement (non-REM). REM sleep is where most dreaming occurs, while non-REM sleep is understood to be deeper and less active. Both parts are essential for healthy, restful sleep.
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Researchers used artificial receptors called designer receptors exclusively activated by designer drugs to increase the activity of Lhx6-expressing neuronsin mice and observed their behaviour.
One population of cells connected to the Lhx6-expressing cells are neurons that are known to secrete hypocretin, a signal that promotes and sustains wakefulness, and which is disrupted in narcolepsy, researchers said.
Using drugs that block hypocretin action, they then showed that the increase in non-REM sleep seen following activation of Lhx6-expressing cells was dependent on hypocretin, but that the increase in REM sleep was not.
"This shows that Lhx6 inhibits not only hypocretin- producing cells, but also other types of wake-promoting cells," said Kai Liu, a graduate student at the Johns Hopkins University School.
The study was published in the journal Nature.
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